The Innocence Files focuses on three different causes of wrongful conviction: prosecutorial misconduct, eyewitness misidentification and the use of unreliable or unvalidated forensic science. Split into three parts — The Evidence, The Witness and The Prosecution — the series follows the individual stories of people working to be exonerated, including Chester Hollman III, Kenneth Wyniemko, Alfred Dewayne Brown, Thomas Haynesworth, Franky Carrillo, Levon Brooks, Kennedy Brewer and Keith Harward.